The role of the skin microbiome in wound healing in in systemic sclerosis
Chronic digital ulcers due to peripheral microangiopathy are a major complication in systemic sclerosis (SSc).
Chronic wounds are often enriched by bacteria without overt clinical signs of infection and inflammation. Data on the role of skin commensal bacteria on wound repair are conflicting with both beneficial and detrimental effects.
A recent study provided evidence for previously unknown direct interactions between skin bacteria, dermal cells and extracellular matrix proteins even in normal skin (Nakatsuji T et al., Nat Commun 2013).
Within the current project, we therefore investigated whether skin commensal bacteria are involved in the aberrant wound healing responses in SSc by using bacterial co-culture systems, a 3D skin model and representative animal models.
Source: Eming SA, et al. Sci Transl Med (2014)