Role of circulating monocyte in SSc
Monocytes represent a part of white blood cells, which are basically responsible for fast interventions against pathogens invading our bodies, such as bacteria, parasites and fungi. In case of body/tissue damages, they are developing inflammation and mobilizing another cell types in wound healing and regeneration. However, dysregulated immune system can sustain inflammation that leads to fibrosis.
We are addressing the question what is the exact role of monocytes in the development of pathological multiorgan fibrosis in SSc patients. Additionally, we believe that detailed observation of monocyte activation state might be an indicator of disease progression and response to the treatment.
Swiss National Science Foundation, Swiss Heart Foundation