Role of specific myeloid and stromal cells in multiorgan remodelling in SSc
Based on our preliminary data, we hypothesize that specific stromal or myeloid cell populations might serve as cellular sources of pathological myofibroblasts not only in myocardial but generalized in multiorgan fibrosis in SSc. We hope that the outcomes of this project might be valuable for: i) further characterization of stromal or myeloid cells derived from different organs (cell similarity or discrepancy) during homeostasis and under pathological conditions, ii) foster evaluation of the impact of Fos-related antigen (Fra)-2 on the development and function of specific stromal or myeloid cell populations, iii) giving reliable hints on the mechanisms behind the Fra-2-driven profibrotic phenotype.
We believe that the insights from this project might contribute to general and unifying mechanistic concepts in the physiopathology of fatal multiorgan fibrosis and dysfunction not only in SSc but in other fibroproliferative disorders.
Prof. Dr. B. Becher, Institute of Experimental Immunology, University of Zurich.
Swiss National Science Foundation, Swiss Heart Foundation, Swiss Life Jubiläumsstiftung