Mechanism of multiorgan remodelling in Systemic Sclerosis
Understanding the cellular and molecular bases of multiorgan fibrogenesis leading to the fatal organ remodelling in Systemic Sclerosis (SSc) is crucial for identifying potential diagnostic and therapeutic targets. Inflammation, fibrosis and vasculopathy are the hallmarks of the rare, autoimmune disease SSc. During the last years, there was a shift in SSc-related death causes, indicating inflammatory dilated cardiomyopathy and cardiac arrhythmias as major causes of death in these patients. Nevertheless, despite the high unmet clinical need, so far little is known about the etiology of SSc pathogenesis and the mechanisms leading to multiorgan dysfunction in SSc patients.
We are interested to study the role of specific stromal cell and inflammatory myeloid cell compartments in multiorgan fibrogenesis and pathological remodelling, as well to determine the origin of pathological myofibroblasts and their cellular sources in SSc. We are particularly focusing on the cell-to-cell interaction during the process of multiorgan inflammation and fibrogenesis, and on the molecular mechanisms that drive this complicated signalling orchestra.
Our running projects / our ultimate interests: