3D skin model

Current in vitro models for skin diseases are based on cell monolayers, not considering the complex interaction within the 3-dimensional architecture of organs and the interactions of cells and the environment. Consequently, we observe a rather poor predictable power of pre-clinical cell-based drug screening assays. To address this gap in drug development, researchers have become increasingly interested in culture systems in which the cells produce their own microenvironment and mimic thereby the in vivo situation. 

Synthetic nanofibrous scaffolds have become apparent alternatives for 3D skin tissue engineering, especially for skin. Electrospinning of PCL creates nanofibers that show morphological similarities to native collagen fibrils in size and orientation.

Our aim is to create skin equivalents with primary skin fibroblasts and keratinocytes and stepwise multicellular systems containing endothelial cells and immune cells.

Funding
Novartis Stiftung

Collaborations

• Markus Rimann (ZHAW)
• Karin Würtz (Rochester Institute of Technology, USA)
  

Project overview

• Development of humanized 3D skin models for Systemic sclerosis (SSc)
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MSc Thesis available: please contact Stefan Dudli / Astrid Jüngel