Observational studies

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               Dr. Suzana Jordan
              Group leader

Systemic sclerosis is a rare autoimmune connective tissue disease with major hallmark- fibrosis of skin and inner organs. It is very heterogeneous with variety of disease facets. Collecting of patients' data and biosamples on a local and international level and further observational cohort and biomarker research provides a huge insight in prediction, diagnosis and management of this devastating, lethal disease with the highest mortalily among rheumatic diseases.

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Current studies

  • Einfluss von Schmerzen, Ulcera und Arthritis auf die Handfunktion bei Patienten mit systemischer Sklerose
  • Wirksamkeit und Sicherheit von Tocilizumab auf Patienten mit systemischer Sklerose: die Analyse der EUSTAR Datenbank
  • The burden of systemic sclerosis in Switzerland- disease characteristics the therapeutic management of patients from specialized Swiss centres
  • PAH incidence early, mild and established SSc
  • Hemiplegia in SSc EUSTAR cohort 
  • Quantifizierung der HRCT und Vergleich mit Daten aus Norwegen
  • Calcineurin inhibitors
  • Improvement of skin fibrosis and effect to survival and lung fibrosis improvement
  • Patient global Assessment, HAQ-DI and Physician Global Assessment beschreiben
  • Konsensusfindung für biologische, bildgebende und klinische Marker zur Prädiktion der Entwicklung einer sehr frühen in die definitive systemische Sklerose
  • Therapeutic management of progressive fibrosis in Swiss SSc patients
  • Efficacy and safety of riociguat in EUSTAR cohort
  • U1RNP positive patients in EUSTAR cohort
  • Biomarkers Type III and type IV collagen predict progression of fibrosis in established systemic sclerosis
  • Biomarkers in very early cohort of SSc
  • Healing biomarkers in SSc
  • Muscle function or physical performance of patients with systemic sclerosis-associated myopathy 
  • Therapie-Outcome von Patienten mit Grossgefässvaskulitis und Periaorti¬tis in der Rheumatologie Zürich 
  • Clinical correlates and relevance of UCLA GIT 2.0 for esophagitis and indication for esophagogastroduodenoscopy in real-life patients with systemic sclerosis
  • The enigma of mixed connective tissue disease – challenges in routine care
  • Hospital Anxiety and Depression Scale and Sense of Coherence 13-item scale in a Swiss Cohort of Systemic Sclerosis patients: Validity, and Sensitivity to Change  


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