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3D cardiac microtissue remodelling models

3D cardiac microtissues, composed of human-induced pluripotent stem cells and human cardiac fibroblasts, provide an organoid human-based cellular platform that is free of scaffold and necrosis, and recapitulates vital cardiac functionality mimicking contractility and electrophysiological responses.

We aim to establish 3D cardiac models of fibrosis and microvasculopathy with further evaluation of their characteristic and functions. Cell-to-cell integration in 3D in vitro model offers an excellent tool to study cell/tissue/organ physiology and pathology in SSc.

Funding

Swiss Heart Foundation
Gebauer Foundation
Vontobel Foundation

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