Role of myeloid cells in myocardial remodelling in SSc

Myeloid cells function as antigen-presenting cells and as potent producers of pro-inflammatory or anti-inflammatory factors.  Myeloid cells also affect the differentiation of neighbouring cells and cell progeny and modulate the local signalling milieu. In this manner, myeloid cells can actively contribute to the pathogenesis of inflammatory diseases, including SSc.

We showed the importance of Fos-related antigen (Fra)-2 in the regulation of activation stage of myeloid populations, namely monocytes and macrophages in SSc, therefore we plan further to investigate the role of myeloid populations in pathogenesis of SSc. To this aim we will focus on cell-to-cell interaction and on single cell level.

Funding

Swiss National Science Foundation
Swiss Heart Foundation

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