Role of circulating monocytes in SSc
Monocytes represent a part of white blood cells, which are basically responsible for fast interventions against pathogens invading our bodies, such as bacteria, parasites and fungi. In case of body/tissue damages, they develop inflammation and mobilize other cell types in wound healing and regeneration. However, dysregulated immune system can sustain inflammation that leads to fibrosis.
We are addressing the question of what the exact role of monocytes is in the development of pathological multiorgan fibrosis in SSc patients. Additionally, we believe that detailed observation of monocyte activation state might be an indicator of disease progression and response to the treatment.
Swiss National Science Foundation
Swiss Heart Foundation