Role of specific stromal and myeloid cells in multiorgan remodelling in SSc
We hypothesize that specific stromal or myeloid cell populations might either serve as cellular sources of pathological myofibroblasts or activate fibrogenesis not only in myocardial but generalized in multiorgan fibrosis in SSc.
We believe that the insights from this project might contribute to general and unifying mechanistic concepts in the physiopathology of fatal multiorgan fibrosis and dysfunction not only in SSc but in other fibroproliferative disorders. To this aim we will focus on cell-to-cell interaction and on single cell level.
Swiss National Science Foundation
Swiss Heart Foundation