Role of stromal cell population in myocardial remodelling in SSc
Specific stromal cell population serves as cellular sources of pathological myofibroblasts- key players in the heart remodelling in SSc. We pointed to the key role of Transforming Growth Factor (TGF)-β and Fos-related antigen (Fra)-2 in the fatal cardiac remodelling in SSc. To this aim we will focus on cell-to-cell interaction and on single cell level.
Swiss National Science Foundation
Swiss Life Jubiläumsstiftung