Role of stromal cell population in myocardial remodelling in SSc

Specific stromal cell population serves as cellular sources of pathological myofibroblasts- key players in the heart remodelling in SSc. We pointed to the key role of Transforming Growth Factor (TGF)-β and Fos-related antigen (Fra)-2 in the fatal cardiac remodelling in SSc. To this aim we will focus on cell-to-cell interaction and on single cell level.

Funding:

Swiss National Science Foundation
Novartis Stiftung
Egli Stiftung
Forschungskredit
Swiss Life Jubiläumsstiftung

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